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However, the development of ex vivo slice culture models has provided an alternative model that bridges the gap between in vitro and in vivo models, enabling the investigation of demyelination and remyelination under controlled conditions, with the added advantage of reduced cost and ethical considerations (Humpel, 2015)

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Disclosures Disclosure forms, as provided by each author, are available with the online version of the article at Author Contributions Conceptualization: Yuki Sugiura, Motoko Yanagita

J Clin Invest 94:437444 Brennan ML, Penn MS, Van LF, Nambi V, Shishehbor MH, Aviles RJ, Goormastic M, Pepoy ML, McErlean ES, Topol EJ, Nissen SE, Hazen SL (2003) Prognostic value of myeloperoxidase in patients with chest pain